Cytoplasmic nucleic acid sensors
WebMar 29, 2024 · In recent years, increasing research works are pushing the limit of nucleic acid sensors in preclinical applications and imaging-guided therapy. However, the applicability of current nucleic acid sensors in vivo is largely hindered by the complexity of living animals. ... Since APE1 is only present in the cytoplasm of inflammatory cells but … WebFeb 22, 2016 · Nucleic acid sensing is a key element of antimicrobial immunity (Wu & Chen, 2014 ). Diverse nucleic acid sensors act as pattern recognition receptors (PRRs), initiating innate immune responses necessary to protect against pathogens containing a diverse range of nucleic acid species (Wu & Chen, 2014 ).
Cytoplasmic nucleic acid sensors
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WebSep 1, 2009 · Cellular sensors for DNA and RNA ends are generally studied as triggers for the repair of somatic mutations but they also have a role in sensing viral nucleic acids … WebMar 22, 2024 · (A) Schematic representation of the components, including digitally barcoded nanoparticles, microfluidic cartridge, and an integrated instrument for the detection of molecular biomarkers (B) Working principle of the nucleic acid-based nanotweezer sensor (C) MTase activity uncovering by padlock probe with RCA technique (D) Multi-view of the …
WebWhile nucleic acid sensors can also sense endogenous nucleic acids, they are capable of discriminating self from non-self. However, defects in nucleic acid sensing PRRs or … WebMar 11, 2024 · Cytoplasmic nucleic acid sensors were initially described as intracellular pattern recognition receptors that initiate innate immune responses to viral and other …
WebOct 28, 2024 · The authors also suggested that as well as acting as a downstream sensor of cytoplasmic mtDNA, NLRP3 also contributes to mtDNA release by facilitating mPTP formation in the mitochondria inner membrane (Nakahira et al., 2011). ... L1 cDNA accumulates in the cytoplasm in aging and disease, where it is sensed by nucleic acid … Webrecognize pathogen-derived nucleic acids are present in vesicular compartments and in the cytosol of most cell types. Here, we review recent studies of these cyto-solic sensors, …
WebThe cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence or to the activation of defense mechanisms. DNA is normally found in the nucleus of the cell. Localization of DNA to the cytosol is associated …
WebJun 28, 2012 · Recently, some new sensors for viral RNA or DNA have been reported, such as HMGBs, IFI16, IFIT1, and DDX41 (16, 17, 32, 33). These molecules recognize different types of nucleic acids or function in different cell types. Despite the progress in recent years, how viral nucleic acids are recognized by host cells is still enigmatic. thorens tp 90 tonarmWebp202 is another member of the PYHIN family shown to bind cytoplasmic dsDNA but, in contrast to AIM2, it represses ... Yang P. et al., 2010. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type … thorens tribute to a legendWebEnrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind nucleic acids: Author: Luisa Gabriel Bharath Srinivasan Krzysztof Kus Alekos Athanasiadis : DOI: 10.1101/2024.01.20.427402: Comments: Category: Subjects ultra tow folding rampsWebDec 28, 2024 · SASP is mediated by the activation of cytoplasmic nucleic acid sensors. However, the molecular mechanism underlying the accumulation of nucleotide ligands in senescent cells is unclear. In this ... ultra tow led lightsWebFeb 7, 2015 · These sensors induce expression of cytokines, affect cellular functions required for virus replication and directly target viral nucleic acids through degradation or sequestration. ultratownWebJun 22, 2024 · Unsurprisingly, host cells are equipped with multiple sensors for nucleic acid detection. In mammals, cytoplasmic nucleic acid sensors have a key role in the … ultratown ltdWebJan 1, 2024 · Indeed, several cytosolic sensors in the family of NLRs such as NOD2, NLRP3, NLRP6, and NLRP12 have been shown to play a central role in intestinal homeostasis and their defects are associated with colitis and colitis-associated colorectal cancer ( Elinav et al., 2011; Hugot et al., 2001; Udden et al., 2024; Zaki et al., 2010, Zaki … thorens tp 95